10 Prescription Drugs That Can Impact Male Fertility - Drug

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Women might also make up the majority of patients with a diagnosis of chronic Lyme simply because their Lyme may be less likely to meet the official diagnostic criteria for more accepted forms of the disease. Many women experience an aching back due to the unbalanced weight gain caused by pregnancy, while others suffer the residual pain of back labor. Brian Fallon, a Columbia scientist who just published Conquering Lyme Disease: Science Bridges the Great Divide, reviewed all of these trials and concluded that "approximately 60 percent of patients with persistent post-treatment Lyme fatigue may experience meaningful but partial clinical improvement in fatigue with antibiotic retreatment." The trials did conclude that there wasn’t enough evidence for a clinical recommendation for antibiotic treatment, but that was only because they studied intravenous antibiotics, and delivering drugs intravenously introduces all kinds of additional risks to the patient, which complicates the calculation around overall benefit. Let’s do the science and figure this disease out.



Take, for example, the fact that women’s overrepresentation among chronic Lyme patients has long been used to suggest there’s no real disease to see here. If women are both more likely to have chronic symptoms after being treated for early Lyme and less likely to have their late Lyme symptoms recognized because the blood tests systemically underdiagnosed them, then their overrepresentation among chronic Lyme patients isn’t a mystery-or an argument against its existence. This is thought to be part of the reason that women are prone to autoimmune disease and may well be relevant to the disparity in their experiences with Lyme disease. The main reason we don’t have answers to those questions yet is that we’ve barely tried to find them. More recently, some skeptics have pointed to the gender imbalance among chronic Lyme patients to bolster their argument that, while PTLDS may be a real thing, most "chronic Lyme" is just the result of misdiagnosis.



On top of that, Lyme disease is not the only tick-borne illness. We need to understand the differences in how men and women are affected by the disease. Yet we know that women’s immune systems are substantially different than men’s, which may be rooted in the fact that women have to allow another creature, a baby, to grow inside them without immune attack. We need to know if some patients are suffering from persistent infections. But they can be as bad as, or worse than, Lyme disease itself-a 2016 article in the New England Journal of Medicine reported that .38 percent of blood-donation samples were contaminated with Babesia, causing at least four deaths between 2010 and 2014. Many of these bugs are not killed off by the standard antibiotic treatment for Lyme, so even if B. burgdorferi has been eradicated, patients may be suffering from infection with something else. But that’s rather the point: The skeptics act as though the science is already settled, when in actuality, patients are suffering desperately for lack of science.



That means that ironically, those who howl that chronic Lyme is "fake" BECAUSE SCIENCE aren’t just being unscientific, they’re also impeding science. What is most frustrating about the public conversation around chronic Lyme is that it often fails to recognize that science is an iterative, imperfect process. Self-described "Lyme-literate" doctors who will diagnose patients with chronic Lyme often treat them with repeated-or even long-term-courses of antibiotics. But a researcher who ran one of those trials says that they’ve been badly misinterpreted. The mainstream position is that this is not a reasonable course of action, as four clinical trials of long-term, intravenous antibiotic treatment for PTLDS have proven that they don’t work. Instead, it’s an indictment of diagnostic criteria and a treatment paradigm that appears to be letting many Lyme patients, the majority of them women, fall through the cracks. The reasons are many, as Pamela Weintraub describes in Cure Unknown: Inside the Lyme Epidemic. There are so many different dance styles available that it would be impossible to list all of them. Recent studies suggest that disease is not transmitted via tick, and since the data seems inconclusive, it has been removed from the original list.